Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.
Moderate Confidence RCTPrimary source: [Open]
Linked compounds: matrixyl
Outcomes summary
Double-blind, randomized trial comparing topical acetylhexapeptide-3, palmitoyl pentapeptide-4 (Matrixyl), and placebo for crow’s feet, reporting measurable improvements in some subjects with palmitoyl pentapeptide-4 showing better overall results than comparator arms in this small study.
Limitations
Small sample size and short duration; cosmetic endpoints; results are formulation- and population-specific.
Notes
Primary source: PMID 36909866.