Matrixyl
Also known as: Palmitoyl Pentapeptide-4
Last updated: 1/23/2026 Last reviewed: 1/23/2026
At a Glance
Matrixyl is a trade name commonly associated with palmitoyl pentapeptide-4, a cosmetic peptide used in topical formulations. Evidence and tolerability depend on the specific product and use.
⚠️ Educational Only: This page summarizes cosmetic research and intentionally does not include protocols/dosing.
Mechanism of Action (TBD)
Often described as supporting extracellular-matrix–related signaling in skin (e.g., collagen-related pathways), but mechanism claims should be validated against primary sources for a given formulation.
Evidence Summary
Crow’s feet (Double-blind randomized trial)
Moderate Confidence RCT ≤3 YearsA small double-blind randomized trial compared palmitoyl pentapeptide-4 cream with comparator arms and placebo for crow’s feet, reporting measurable improvements in some subjects. [PMID: 36909866]
Safety & Unknowns
- Topical tolerability varies by formulation and individual sensitivity.
- Cosmetic endpoints and short study durations limit generalizability.
Regulatory Status
| Region | Status |
|---|---|
| United States (FDA) | Cosmetic ingredient (not an approved drug) |
| European Union (EMA) | Cosmetic ingredient (not an approved drug) |
| WADA | Not typically addressed as a drug class; check current list if relevant |
Changelog
| Date | Change |
|---|---|
| 2026-01-23 | Added dossier and linked primary literature |