Hyperglycemic action of synthetic C-terminal fragments of human growth hormone.
Low Confidence Animal StudyPrimary source: [Open]
Linked compounds: frag-176-191
Outcomes summary
In normal rats, several synthetic C-terminal fragments of human growth hormone (including the 176–191 region) produced transient hyperglycemia and more sustained hyperinsulinemia, with evidence of reduced insulin sensitivity in tolerance testing.
Limitations
Animal study; synthetic fragments and dosing paradigms may not translate to human physiology; mechanistic inference is limited.
Notes
Primary source: PMID 645904.