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IUPHAR review: From foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes.

review • 2026 • ID: 41478576

Moderate Confidence Review

Primary source: [Open]

Linked compounds: retatrutide

Outcomes summary

IUPHAR review summarizing glucagon receptor biology and how glucagon signaling is being leveraged in obesity/metabolic disease drug design (including multi-agonist strategies).

Limitations

Review-level evidence; does not provide clinical efficacy estimates for any single drug and should be interpreted alongside trial data.

Notes

Primary source: PMID 41478576 (see PubMed link on this page).