Tesamorelin

At a Glance

Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) used clinically for HIV-associated lipodystrophy (visceral adiposity).

Mechanism of Action (High Level)

By stimulating GHRH receptors, tesamorelin can increase pulsatile growth hormone secretion and downstream IGF-1 signaling.

Evidence Summary

Clinical evidence and regulatory use are largely centered on HIV-associated lipodystrophy and changes in visceral adiposity. [PMID: 21668043]

Safety & Unknowns (High Level)

• Effects relate to GH/IGF-1 biology; safety considerations may include glucose metabolism and other GH/IGF-1–related effects depending on population and baseline risk.

Key Studies

📚 See linked items in the Literature section.