Bremelanotide

At a Glance

Bremelanotide (also known as PT-141) is a melanocortin receptor agonist with clinical research and approval for a sexual health indication.

Mechanism of Action (High Level)

Melanocortin receptor agonism is implicated in central pathways involved in sexual desire and arousal. The receptor subtype(s) responsible for clinical effects can be context-dependent.

Evidence Summary

Two randomized Phase 3 trials evaluated bremelanotide for hypoactive sexual desire disorder. [PMID: 31599840]

Safety & Unknowns (High Level)

• Central-acting agents can have tolerability considerations; consult primary sources and prescribing information for adverse event profiles and contraindications.

Key Studies

📚 See linked items in the Literature section.