Argireline
Also known as: Acetyl Hexapeptide-8
At a Glance
Argireline (acetyl hexapeptide-8) is a cosmetic peptide used in topical products. Evidence and tolerability are formulation- and use-pattern dependent, and outcomes are typically cosmetic (appearance-based) rather than disease endpoints.
⚠️ Educational Only: This page summarizes cosmetic research and intentionally does not include protocols/dosing.
Mechanism of Action (TBD)
Often described in cosmetic literature as influencing wrinkle appearance via peptide signaling effects in skin and neuromuscular junction–adjacent framing; mechanism claims should be validated against primary sources for a given formulation.
Evidence Summary
Anti-wrinkle efficacy (Randomized Trial)
Moderate Confidence RCT 3-10 YearsA randomized, placebo-controlled study in Chinese subjects reported anti-wrinkle efficacy on assessed endpoints. [PMID: 23417317]
Safety & Unknowns
- Topical tolerability varies by formulation and individual sensitivity.
- Effects are cosmetic and may not generalize across products or concentrations.
Regulatory Status
| Region | Status |
|---|---|
| United States (FDA) | Cosmetic ingredient (not an approved drug) |
| European Union (EMA) | Cosmetic ingredient (not an approved drug) |
| WADA | Not typically addressed as a drug class; check current list if relevant |
Changelog
| Date | Change |
|---|---|
| 2026-01-23 | Added dossier and linked primary literature |